Marie Stiborova Selected Research

ellipticine

2/2019	Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.
1/2019	Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine.
12/2016	Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.
9/2015	Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.
1/2015	Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.
6/2012	Study of DNA-ellipticine interaction by capillary electrophoresis with laser-induced fluorescence detection.
6/2012	Analysis of covalent ellipticine- and doxorubicin-derived adducts in DNA of neuroblastoma cells by the ³²P-postlabeling technique.
1/2011	Anticancer agent ellipticine combined with histone deacetylase inhibitors, valproic acid and trichostatin A, is an effective DNA damage strategy in human neuroblastoma.
9/2010	alpha5beta1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells.
1/2010	Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

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Marie Stiborova Research Topics

Disease

41	Neoplasms (Cancer) 01/2020 - 07/2002
10	Prostatic Neoplasms (Prostate Cancer) 07/2022 - 07/2013
10	Balkan Nephropathy (Balkan Endemic Nephropathy) 01/2019 - 10/2002
8	Neuroblastoma 01/2018 - 01/2011
4	Carcinogenesis 01/2019 - 07/2002
4	Body Weight (Weight, Body) 01/2019 - 03/2006
3	Brain Neoplasms (Brain Tumor) 11/2016 - 01/2009
3	Cardiotoxicity 01/2016 - 10/2013
2	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 05/2015
2	Neoplasm Metastasis (Metastasis) 02/2019 - 01/2016
2	Breast Neoplasms (Breast Cancer) 02/2019 - 11/2016
2	Leukemia 11/2016 - 01/2015
2	Lung Neoplasms (Lung Cancer) 11/2016 - 03/2008
2	Heart Failure 01/2016 - 10/2013
2	Inflammation (Inflammations) 08/2015 - 01/2014
2	Carcinoma (Carcinomatosis) 06/2015 - 09/2010
2	Glioblastoma (Glioblastoma Multiforme) 09/2010 - 01/2009
2	Chronic Kidney Failure (Chronic Renal Failure) 03/2009 - 10/2008
2	Fibrosis (Cirrhosis) 03/2009 - 10/2008
1	Colonic Neoplasms (Colon Cancer) 01/2020
1	Rectal Neoplasms (Rectal Cancer) 01/2020
1	Hypoxia (Hypoxemia) 09/2017
1	Multiple Myeloma 07/2017
1	T-Cell Lymphoma (Lymphoma, T Cell) 07/2017
1	Cardiomyopathies (Cardiomyopathy) 01/2016

Drug/Important Bio-Agent (IBA)

14	Pharmaceutical PreparationsIBA 07/2022 - 07/2002
13	aristolochic acid I (aristolochic acid)IBA 01/2019 - 07/2002
12	ellipticineIBA 02/2019 - 07/2006
10	EnzymesIBA 01/2020 - 03/2006
8	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2011
7	DNA AdductsIBA 01/2015 - 07/2002
6	AntibodiesIBA 07/2022 - 01/2014
6	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2018 - 06/2012
5	Antineoplastic Agents (Antineoplastics)IBA 02/2019 - 01/2009
5	Proteins (Proteins, Gene)FDA Link 11/2018 - 12/2012
5	Sarcosine (Methylglycine)IBA 02/2018 - 07/2013
5	Histone Deacetylase InhibitorsIBA 07/2017 - 01/2011
4	Biomarkers (Surrogate Marker)IBA 01/2019 - 07/2013
4	Cisplatin (Platino)FDA LinkGeneric 01/2018 - 03/2014
4	Valproic Acid (Depakote)FDA LinkGeneric 09/2017 - 01/2011
4	ZincIBA 11/2016 - 12/2012
4	MetallothioneinIBA 01/2016 - 01/2010
3	ApoferritinsIBA 07/2022 - 06/2016
3	Cytochrome P-450 CYP3AIBA 01/2020 - 01/2011
3	Amino Acids FDA Link 01/2019 - 01/2016
3	IonsIBA 11/2016 - 01/2015
3	Liposomes (Liposome)IBA 02/2016 - 12/2014
3	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 08/2015 - 01/2011
2	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2016
2	XenobioticsIBA 01/2020 - 05/2015
2	Biological ProductsIBA 01/2020 - 09/2017
2	AntigensIBA 11/2018 - 06/2016
2	PlatinumIBA 09/2017 - 01/2016
2	AntioxidantsIBA 09/2017 - 03/2014
2	Serine (L-Serine)FDA Link 05/2016 - 01/2016
2	Histones (Histone)IBA 01/2016 - 06/2014
2	Etoposide (VP 16)FDA LinkGeneric 07/2015 - 01/2012
2	Histone Deacetylases (Histone Deacetylase)IBA 07/2015 - 01/2012
2	AlkaloidsIBA 06/2012 - 10/2008
1	UGT1A8 UDP-glucuronosyltransferase (UGT1A8)IBA 01/2020
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2020
1	Cytochrome P-450 CYP2C9IBA 01/2020
1	bilirubin uridine-diphosphoglucuronosyl transferase 1A10 (UGT1A10)IBA 01/2020
1	A-Form DNA (A-DNA)IBA 02/2019
1	Messenger RNA (mRNA)IBA 01/2018
1	Adenine FDA LinkGeneric 09/2017
1	Oxaliplatin (Eloxatin)FDA LinkGeneric 09/2017
1	CytosineIBA 09/2017
1	Carboplatin (JM8)FDA LinkGeneric 09/2017
1	romidepsin (FK228)FDA Link 07/2017
1	Vorinostat FDA Link 07/2017
1	PanobinostatIBA 07/2017
1	belinostatIBA 07/2017
1	Glutamic Acid (Glutamate)FDA Link 05/2016
1	Aspartic Acid (Aspartate)FDA Link 05/2016
1	Free RadicalsIBA 01/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2016
1	IronIBA 01/2016
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2016
1	MetalsIBA 01/2016
1	ChromatinIBA 01/2016
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2016
1	Complementary DNA (cDNA)IBA 01/2016
1	AnthracyclinesIBA 01/2016
1	Protein Isoforms (Isoforms)IBA 01/2016
1	Sarcosine DehydrogenaseIBA 01/2016
1	Glycine N-Methyltransferase (Glycine Sarcosine N-Methyltransferase)IBA 01/2016
1	Cytostatic AgentsIBA 01/2016
1	dimethylglycineIBA 01/2016
1	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2016
1	Chloroquine (Aralen)FDA LinkGeneric 09/2015
1	Adenosine Triphosphatases (ATPase)IBA 09/2015
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 09/2015
1	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 08/2015
1	Air Pollutants (Pollutants, Air)IBA 08/2015

Therapy/Procedure

8	Therapeutics 07/2017 - 09/2010
3	Drug Therapy (Chemotherapy) 01/2017 - 09/2010
2	Aftercare (After-Treatment) 06/2016 - 01/2016
1	Precision Medicine 01/2019
1	Radiotherapy 07/2017